Mitsuru Hashida Selected Research

Firefly Luciferases

9/2013	Pivotal role of oxidative stress in tumor metastasis under diabetic conditions in mice.
2/2012	Development of bone-targeted catalase derivatives for inhibition of bone metastasis of tumor cells in mice.
1/2010	Simultaneous delivery of doxorubicin and immunostimulatory CpG motif to tumors using a plasmid DNA/doxorubicin complex in mice.
8/2008	Hydrogen peroxide-mediated nuclear factor kappaB activation in both liver and tumor cells during initial stages of hepatic metastasis.
1/2008	Insertion of nuclear factor-kappaB binding sequence into plasmid DNA for increased transgene expression in colon carcinoma cells.
5/2007	Inhibition of peritoneal dissemination of tumor cells by cationized catalase in mice.
11/2006	PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal.
10/2006	Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/cationic liposome complex.
12/2005	Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes.
11/2004	Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: quantitative analysis with firefly luciferase-expressing melanoma cells.

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Mitsuru Hashida Research Topics

Disease

58	Neoplasms (Cancer) 01/2022 - 04/2002
25	Neoplasm Metastasis (Metastasis) 12/2021 - 04/2002
14	Melanoma (Melanoma, Malignant) 12/2021 - 11/2004
7	Inflammation (Inflammations) 11/2014 - 02/2007
6	Reperfusion Injury 01/2016 - 01/2008
5	Carcinoma (Carcinomatosis) 08/2014 - 05/2002
4	Adenocarcinoma 12/2019 - 12/2005
4	Hepatocellular Carcinoma (Hepatoma) 04/2007 - 02/2003
3	Lung Neoplasms (Lung Cancer) 10/2013 - 02/2006
2	Breast Neoplasms (Breast Cancer) 01/2016 - 08/2010
2	Adenocarcinoma of Lung 01/2016 - 01/2016
2	Acute Liver Failure (Fulminant Hepatic Failure) 04/2014 - 01/2006
2	Ischemia 07/2012 - 01/2008
2	Experimental Melanoma 02/2012 - 12/2005
2	Pneumonia (Pneumonitis) 01/2011 - 11/2008
2	Body Weight (Weight, Body) 05/2009 - 01/2004
2	Colonic Neoplasms (Colon Cancer) 09/2007 - 09/2006
1	Hyperthermia 07/2020
1	Eye Diseases (Eye Disease) 11/2017

Drug/Important Bio-Agent (IBA)

20	Liposomes (Liposome)IBA 03/2016 - 04/2002
15	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 06/2003
15	CatalaseIBA 02/2012 - 05/2002
10	Firefly LuciferasesIBA 09/2013 - 11/2004
9	catalase-polyethylene glycolIBA 09/2013 - 05/2002
8	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 09/2013 - 01/2006
7	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016 - 05/2006
7	Peptides (Polypeptides)IBA 01/2016 - 04/2006
7	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2016 - 11/2004
7	CytokinesIBA 11/2014 - 09/2003
7	LuciferasesIBA 09/2013 - 11/2004
6	DNA VaccinesIBA 12/2021 - 07/2007
6	Pharmaceutical PreparationsIBA 01/2016 - 09/2006
6	LipopolysaccharidesIBA 11/2014 - 06/2006
6	NF-kappa B (NF-kB)IBA 01/2014 - 02/2007
5	Tretinoin (Retinoic Acid)FDA LinkGeneric 09/2014 - 02/2006
5	Small Interfering RNA (siRNA)IBA 09/2014 - 06/2010
4	Lysine (L-Lysine)FDA Link 12/2021 - 12/2006
4	A-Form DNA (A-DNA)IBA 12/2021 - 04/2011
4	Proteins (Proteins, Gene)FDA Link 06/2020 - 01/2014
4	AntigensIBA 06/2020 - 07/2007
4	Alanine Transaminase (SGPT)IBA 01/2016 - 01/2008
4	Dendrimers (Dendrons)IBA 01/2016 - 12/2006
4	LipidsIBA 11/2014 - 04/2006
4	Mannose (D-Mannose)IBA 11/2014 - 04/2011
4	SolutionsIBA 08/2014 - 09/2007
4	EnzymesIBA 02/2012 - 05/2002
3	VaccinesIBA 12/2021 - 11/2014
3	Indicators and Reagents (Reagents)IBA 07/2018 - 11/2004
3	Doxorubicin (Adriamycin)FDA LinkGeneric 06/2015 - 01/2010
3	Messenger RNA (mRNA)IBA 01/2014 - 07/2006
3	Aspartate Aminotransferases (Aspartate Transaminase)IBA 11/2009 - 01/2008
3	MicellesIBA 05/2009 - 12/2005
3	EmulsionsIBA 05/2009 - 09/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2006 - 09/2003
2	diazonaphthalenedisulfonic acid (NDS)IBA 07/2020 - 12/2019
2	Drug CarriersIBA 11/2017 - 09/2006
2	LigandsIBA 01/2017 - 09/2006
2	Amino Acids FDA Link 01/2016 - 08/2010
2	Cysteine (L-Cysteine)FDA Link 01/2016 - 09/2006
2	Sulfhydryl Compounds (Thiols)IBA 01/2016 - 04/2014
2	Mucin-1 (CA 15-3 Antigen)IBA 01/2016 - 01/2012
2	Heparin (Liquaemin)FDA LinkGeneric 11/2014 - 11/2014
2	Carbon Nanotubes (Carbon Nanotube)IBA 08/2014 - 01/2014
2	Bovine Serum AlbuminIBA 04/2014 - 01/2008
2	GalactosamineIBA 04/2014 - 07/2009
2	PolyethyleneimineIBA 01/2012 - 02/2003
2	Interleukin-12 (IL 12)IBA 01/2010 - 10/2006
2	Therapeutic UsesIBA 12/2009 - 09/2003
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2009 - 01/2008
2	HydrogelsIBA 07/2009 - 09/2007
2	EndotoxinsIBA 07/2009 - 11/2008
2	Transcription Factors (Transcription Factor)IBA 08/2008 - 02/2007
2	Lipid PeroxidesIBA 01/2008 - 11/2006
2	Superoxide DismutaseIBA 01/2008 - 06/2006
2	ethylenediamine (ethylenediamine dihydroiodide)FDA Link 09/2007 - 05/2007
2	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 06/2007 - 09/2006
2	lysyl- arginyl- threonyl- glycyl- glutaminyl- tyrosyl- lysyl- leucyl- cysteineIBA 06/2007 - 09/2006
2	1,2- dioleoyloxy- 3- (trimethylammonium)propaneIBA 11/2006 - 02/2006
2	CholesterolIBA 11/2006 - 02/2006
2	AntioxidantsIBA 05/2006 - 12/2005
2	Matrix Metalloproteinases (MMPs)IBA 12/2005 - 01/2004
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 07/2020
1	EpitopesIBA 06/2020
1	peptide SVYDFFVWLIBA 06/2020
1	Monophenol Monooxygenase (Tyrosinase)IBA 06/2020
1	Radioisotopes (Radionuclides)IBA 07/2018
1	Ophthalmic Solutions (Eye Drops)IBA 11/2017
1	HDL LipoproteinsIBA 11/2017
1	Indocyanine Green (Cardio-Green)FDA LinkGeneric 01/2017

Therapy/Procedure

16	Therapeutics 03/2016 - 12/2005
11	Intravenous Injections 11/2009 - 09/2003
5	Immunotherapy 11/2014 - 03/2008
4	Intravenous Administration 03/2009 - 09/2003
3	Drug Therapy (Chemotherapy) 01/2022 - 03/2008
3	Precision Medicine 07/2020 - 06/2015
3	Intraperitoneal Injections 04/2014 - 01/2006
2	Microbubbles 06/2015 - 06/2014
2	Injections 09/2013 - 02/2012
2	Intranasal Administration 01/2012 - 01/2010
2	Operative Surgical Procedures 01/2008 - 11/2006